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Gunther Helms,
Foreign Adjunct Lecturer
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Academic degrees
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Dr. rer. nat. (1994, University of Göttingen) Docent
(2002,
Karolinska
Institutet, Stockholm)
basic training in physics and mathematics, M.Sc. in Physics 1991
Ph.D thesis: RF-Pulses in Spin-Echo
Localization Sequences for in vivo MR Spectroscopy (
in German, revised e-book edition, 7MB pdf)
Summary of Ph.D thesis
(in English)
List of publications
Curriculum vitae
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Contact information
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Academic interests
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| absolute signal
quantification
with application to
clinical
proton MR
spectroscopy in brain |
| magnetization transfer
(MT)
contrast,
theory and quantification of
pulsed MT |
T2-based
volume-segmentation
corrects partial volume effects on scales below voxel resolution
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interaction of scanner and
living
body
physiological motion, RF inhomogeneities
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clever things with EPI,
STEAM, and FLASH MT-quantification, physiological motion,
RF-field mapping (not only
fMRI and DTI)
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information content of
'classical MR-contrast' tissue and lesion segmentation, basic
contrast mechanisms
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Some publications
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Overview of research: Towards
a reliable absolute quantification of in vivo MR Spectra
Overview of research: Towards
an understanding of pulsed MT sequences
PDF-files are listed under fields of research
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Note: upcoming
presentation at the ISMRM,
Miami, May 2005
Poster #2221:
Quantification of magnetization transfer and relaxation rates by
MT-prepared multi-echo EPI
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Note: upcoming
presentation at the ILAE/IBE
Epilepsy Congress in
Paris, August 2005
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Collaboration goodies:
Ethofer T, Mader I, Seeger U,
Helms G, Erb M,
Grodd W, Ludolph A, Klose U.
Comparison of
Longitudinal Metabolite Relaxation Times in Different Regions of the
Human
Brain at 1.5 and 3 Tesla.
Magn Reson Med 2003;
50:1296-1301.
Lehnert A,
Machann J,
Helms G,
Claussen CD, Schick F.
Diffusion
characteristics of
large molecules assessed by
proton MRS on a whole-body MR system.
Magn Reson Imaging 2004;
22: 39-46.
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Current projects
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| Resample strategies to
improve the interpretation of proton
MR-spectra
of low SNR |
| 1H-MRS in
epilepsy (with Ivanka Savic, Human Brain
Research,
KI and Neurology Division, Karolinska University Hospital, Huddinge) |
Quantification of
magnetization transfer in brain tissue
using multi-echo EPI (with Gisela Hagberg, Fondazione Santa
Lucia IRCCS, Rom)
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Hot images:
high-resolution (500 microns
isotropic) MT-maps of basal ganglia
and
thalamic nuclei
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| Tutorings |
Andreas Piringer, 50%
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Strategies for correction
of physiological "noise"
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experimental
neuroscience
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Leszek Stawiarz, 50%
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MRS and MRI in the
progression of multiple sclerosis
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neuroimaging/neurology
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Educational activities
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Recent talks and lectures
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Analysis
of proton MR spectra of the human brain using LCModel: Problems and
Pitfalls
Institute for Clinical
and Experimental Medicine. Prague, Czech Republic. 23 February 2004 |
Quantification
of Magnetization Transfer
by
Sampling the Transient Signal Using MT-prepared ’Single Shot’ EPI
Centre for Functional
Magnetic Resonance Imaging of the Brain
(FMRIB).
University of
Oxford, Oxford, UK. 08 March 2004 |
MR-Spectroscopy shows
syndrom differentiated metabolite
changes in
human generalized epilepsies
12th Annual Meeting of the ISMRM, Kyoto, Japan, 15-22 May 2004. |
Use
of empirical sampling strategies
in MRS evaluation.
Czech-German-Austrian
Meeting on Modern
Techniques in MRI and MRS. Rez, Czech
Republic. 15 October 2004 |
Advanced
quantification of single-volume MRS.
Dept.
Radiation Physics, Lund
University, Sweden. 08 December 2004
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Chemical
exchange revisited: Understanding the physics
of magnetization transfer.
Jubileumsinstitutionen: Dept.
Radiation Physics, Lund
University, Sweden.
19 April 2004.
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Research visits
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| MRC Biochemical and
Clinical
MRS, John Radcliffe Hospital, Oxford, UK |
Peter Styles
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Sept.-Dec. 1997 |
| Biomedical NMR Research
Inc.,
MPI for Biophysical Chemistry, Göttingen, Germany |
Jens Frahm
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July 1998 |
| Fondazione Santa Lucia
IRCCS,
Laboratorio Neuroimmagini, Rome,
Italy |
Gisela Hagberg
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April 2002 |
| Depts.
of Radiology and Physics, University of British
Columbia, Vancouver, BC, Canada |
Alex MacKay
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June 2002 |
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Reviewer for
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Downloads
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Patrick060710
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